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目的:综合评价抗磷脂抗体和子痫前期的关系。方法:对符合纳入标准的13篇文献用Review manager 4.2软件进行Meta分析,计算比值比(0R)、95%可信区间(95%CI)并进行异质性检验,评价发表偏倚并进行敏感性分析。结果:狼疮抗凝物(LA)、抗心磷脂抗体IgG、抗心磷脂抗体IgM、β2糖蛋白-Ⅰ抗体与轻、重度子痫前期相关性的合并OR值及95%CI分别为1.68(0.51,5.54),13.34(4.70,37.84);1.44(0.95,2.20),2.20(0.72,6.75);1.24(0.78,1.98),1.28(0.72,2.29);0.75(0.40,1.43),2.04(0.86,4.82)。结论:LA可能增加重度子痫前期的危险性,对预测子痫前期的妊娠结局有一定作用,有必要对LA进行筛查,更好的服务于子痫前期的诊断和治疗。
Objective: To evaluate the relationship between antiphospholipid antibody and preeclampsia. Methods: Thirteen articles that met the inclusion criteria were analyzed by Meta-analysis using Review manager 4.2 software to calculate the odds ratio (0R), 95% confidence interval (95% CI) and heterogeneity test to evaluate publication bias and sensitivity analysis. Results: The combined OR and 95% CI of lupus anticoagulant (LA), anticardiolipin antibody IgG, anticardiolipin antibody IgM, β2 glycoprotein-I antibody and mild to severe preeclampsia were 1.68 (0.51 , 5.54), 13.34 (4.70,37.84); 1.44 (0.95,2.20), 2.20 (0.72,6.75); 1.24 (0.78,1.98), 1.28 (0.72,2.29); 0.75 (0.40,1.43), 2.04 (0.86, 4.82). CONCLUSION: LA may increase the risk of severe preeclampsia and play a role in predicting the pregnancy outcome of preeclampsia. It is necessary to screen LA and better serve the diagnosis and treatment of preeclampsia.