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目的探讨米力农雾化治疗新生儿及小婴儿重症肺炎合并心力衰竭的疗效及安全性。方法选择240例重症肺炎合并心力衰竭的患儿,随机分为对照组和观察组,每组120例。对照组给予常规洋地黄、利尿等基础治疗;观察组在对照组的基础上加用米力农雾化。观察两组临床疗效和心功能指标的变化。结果治疗5 d后,两组中大部分患者的临床症状、体征及心功能指标均改善,观察组治疗前后各项观察指标的改善均优于对照组,两组治疗后临床疗效和心功能指标差值比较,差异有统计学意义(P<0.05)。结论在常规洋地黄、利尿等治疗基础上,米力农雾化能更快地减低肺循环阻力、减少心脏前负荷和后负荷,从而有效地改善患儿心功能。
Objective To investigate the efficacy and safety of milrinone in the treatment of severe pneumonia complicated with heart failure in neonates and infants. Methods A total of 240 children with severe pneumonia complicated with heart failure were randomly divided into control group and observation group with 120 cases in each group. The control group was given routine treatment of digitalis and diuresis, while the observation group was given Milianon atomization on the basis of the control group. The changes of clinical efficacy and cardiac function in the two groups were observed. Results After 5 days of treatment, the clinical symptoms, signs and cardiac function indexes of most of the two groups were improved. The observation group improved better than the control group before and after treatment. The clinical curative effect and cardiac function index Difference, the difference was statistically significant (P <0.05). Conclusion On the basis of conventional digitalis and diuretic therapy, Milrinone atomization can reduce the resistance of pulmonary circulation more quickly and reduce pre-cardiac load and post-load, so as to effectively improve the cardiac function in children.