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采用ＣＥ方案（卡铂＋足叶乙甙）加放疗治疗小细胞肺癌术后纵隔转移引起的上腔静脉综合征３５例。完全缓解率６７．７％（２３／３５），总有效率为９１．４％（３２／３５）。初治者总有效率为９５．２％（２０／２１），复治者总有效率为８５．７％（１２／１４）。中位生存期１６个月。化疗加放疗优于单纯化疗。本组主要表现血液毒性，恶心呕吐一般在Ⅱ度以下，未出现严重肝、肾毒性。作者认为ＣＥ方案加放疗是治疗小细胞肺癌所致上腔静脉综合征的最佳方案之一。
CE program (carboplatin + etoposide) plus radiotherapy for 35 patients with superior vena cava syndrome caused by mediastinal metastasis after surgery for small cell lung cancer. The complete remission rate was 67.7% (23/35), and the total effective rate was 91.4% (32/35). The total effective rate was 95.2% (20/21) in the initial treatment group, and 85.7% (12/14) in the retreatment group. The median survival period is 16 months. Chemotherapy plus radiotherapy is better than chemotherapy alone. The main manifestation of this group was hematological toxicity. Nausea and vomiting were generally below the second degree and no severe liver and kidney toxicity was observed. The authors believe that CE regimen plus radiotherapy is one of the best options for the treatment of superior vena cava syndrome caused by small cell lung cancer.