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目的制备具有缓释作用的和厚朴酚固体脂质纳米粒。方法采用乳化蒸发-低温固化法制备和厚朴酚固体脂质纳米粒,通过正交试验对处方进行优化,并对其包封率、粒径、体外释放等进行考察。结果制备的固体脂质纳米粒的平均粒径为159 nm,包封率为77.1%。结论乳化蒸发-低温固化法可用于制备和厚朴酚固体脂质纳米粒。
Objective To prepare sustained-release honokiol solid lipid nanoparticles. Methods The emulsifying evaporation-low temperature curing method was used to prepare honokiol solid lipid nanoparticles. Orthogonal test was used to optimize the prescription. The encapsulation efficiency, particle size and in vitro release were also investigated. Results The average particle size of the prepared solid lipid nanoparticles was 159 nm with an encapsulation efficiency of 77.1%. Conclusion Emulsion evaporation - low temperature curing method can be used to prepare honokiol solid lipid nanoparticles.