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目的探讨血清心肌肌钙蛋白I(cTnI)对小儿病毒性心肌炎(VMC)诊断的意义。方法采用化学发光法及免疫抑制法分别测定20例健康儿童(对照组)及56例VMC患儿血清中cTnI及肌酸激酶同工酶(CK-MB)的浓度。结果对照组20例cTnI及CK-MB均在正常范围;56例VMC患儿(VMC组)cTnI及CK-MB分别为(3.10±1.76)μg/L、(29.88±14.27)IU/L,均明显高于对照组(t值分别为7.193、6.064,P均小于0.001),cTnI及CK-MB均阳性者23例,均阴性者4例,cTnI阳性但CK-MB阴性者28例,而cTnI阴性但CK-MB阳性者仅1例;cTnI阳性率(91.1%)明显高于CK-MB(42.9%),差异有极显著性意义(χ2=20.443,P<0.001)。结论测定cTnI对诊断心肌损伤具有高灵敏性及特异性,有利于VMC的早期诊断。
Objective To investigate the significance of serum cardiac troponin I (cTnI) in the diagnosis of viral myocarditis (VMC) in children. Methods The concentrations of cTnI and CK-MB in 20 healthy children (control group) and 56 VMC children were determined by chemiluminescence and immunosuppression. Results The cTnI and CK-MB in the control group were all in the normal range. The cTnI and CK-MB in 56 VMC patients were (3.10 ± 1.76) μg / L and (29.88 ± 14.27) IU / L respectively Were significantly higher than those in the control group (t = 7.193,6.064, P <0.001). There were 23 cases with positive cTnI and CK-MB, 4 cases were negative, 28 cases were cTnI positive and CK-MB negative, The positive rate of cTnI (91.1%) was significantly higher than that of CK-MB (42.9%), the difference was significant (χ2 = 20.443, P <0.001). Conclusion The determination of cTnI in the diagnosis of myocardial injury with high sensitivity and specificity, is conducive to the early diagnosis of VMC.