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Aim:To examine the possible protective effect of ginsenoside Rgl,an activecomponent of ginseng,on lung injury caused by glutamate in vivo.Methods:Thelungs of mice receiving glutamate(0.5 g/kg)and/or ginsenoside Rg1(0.03 g/kg)via intraperitoneal administration were collected.The indexes of lung wet weight/body weight ratios(LW/BW),lung wet/dry weight ratios(W/D),heart rate(HR),and breathing rate(BR)were determined.The activity of nitric oxide synthase(NOS),xanthine oxidase(XOD),superoxide dismutase(SOD),catalase(CAT),thecontent of NO,and malondialdehyde in the lung homogenate were measured.Results:Treatment with glutamate for 2 h increased LW/BW,W/D,HR,and BR.These changes were nearly abolished by pretreatment with ginsenoside Rgl for30 min before glutamate injection.An analysis of the lung homogenate demon-strated the protective effect as evidenced by the inhibition of NOS(12%)andXOD(50%)inactivity,the enhanced activity of SOD(20%)and CAT(25%).Conclusion:Ginsenoside Rgl has a potential protective role in lung diseasesassociated with glutamate toxicity.
Aim:To examine the possible protective effect of ginsenoside Rgl,an active component of ginseng,on lung injury caused by glutamate in vivo.Methods:Thelungs of mice receiving glutamate(0.5 g/kg)and/or ginsenoside Rg1(0.03 g/kg) Via intraperitoneal administration were collected.The indexes of lung wet weight/body weight ratios (LW/BW), lung wet/dry weight ratios (W/D), heart rate (HR), and breathing rate (BR) were determined.The Activity of nitric oxide synthase(NOS),xanthine oxidase(XOD),superoxide dismutase(SOD),catalase(CAT),thecontent of NO,and malondialdehyde in the lung homogenate were measured.Results:Treatment with glutamate for 2 h increased LW/ BW,W/D,HR,and BR.The changes are nearly abolished by pretreatment with ginsenoside Rgl for30 min before glutamate injection.An analysis of the lung homogenate demon-strated the protective effect as evidenced by the inhibition of NOS(12%) andXOD(50%)inactivity,the enhanced activity of SOD(20%)and CAT(25%).Conclusion:Ginsenoside Rgl has a potential Protective role in lung diseasesassociated with glutamate toxicity.