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【目的】为探讨三氧化二砷（Ａｓ２Ｏ３）对胃癌细胞的作用及可能的机制。【方法】用不同浓度的Ａｓ２Ｏ３作用于培养的胃癌细胞株ＭＧＣ－８０３细胞。【结果】噻唑蓝（ＭＴＴ）细胞活力测定显示Ａｓ２Ｏ３能明显抑制ＭＧＣ－８０３细胞生长；进一步用Ｈｏｅｇｈｅｓ３３３４２和碘化丙啶（ＰＩ）双荧光流式细胞仪（ＦＣＭ）检测和琼脂糖ＤＮＡ电泳，ＭＧＣ－８０３细胞表现为明显凋亡特征；扫描电镜显示凋亡的形态学特征。【结论】Ａｓ２Ｏ３能有效地抑制胃癌细胞的生长增殖，并具有时—效和量—效关系。
【Objective】 To investigate the effect of arsenic trioxide (As2O3) on gastric cancer cells and its possible mechanism. 【Methods】 Different concentrations of As2O3 acted on the cultured gastric cancer cell line MGC-803 cells. 【Results】 MTT cell viability assay showed that As2O3 can significantly inhibit the growth of MGC-803 cells; further, Hoeghes33342 and propidium iodide (PI) dual fluorescence flow cytometry (FCM) detection and agarose DNA electrophoresis were used. , MGC-803 cells showed obvious apoptosis characteristics; scanning electron microscopy showed the morphological characteristics of apoptosis. 【Conclusion】As2O3 can effectively inhibit the growth and proliferation of gastric cancer cells, and has a time-effect and dose-effect relationship.