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目的:分析胎儿脉络丛囊肿(CPC)与染色体异常之间的相关性。方法:对2008~2009年间9 833例孕妇行超声检查,发现胎儿脉络丛囊肿166例(1.69%),其中87例行染色体检查,其余随访至分娩后。结果:166例脉络丛囊肿胎儿中,92例为单侧性(55.42%),74例为双侧性(44.58%);合并其他超声异常40例(24.10%),其中胎儿结构畸形7例,其他超声软指标25例,其他超声异常10例;发现染色体异常5例,均为18-三体;大部分脉络丛囊肿于孕28周前消失。结论:胎儿脉络丛囊肿一般于中孕期作出超声诊断,主要与18-三体有关。胎儿单纯脉络丛囊肿预后良好,若合并其他高危因素,如胎儿结构畸形、母亲高龄、双侧多发脉络丛囊肿、其他超声软指标等,则染色体异常风险明显增加,应行羊膜腔或脐血穿刺术以明确染色体核型。
Objective: To analyze the correlation between fetal choroid cyst (CPC) and chromosomal abnormalities. Methods: Ultrasound examination of 9 833 pregnant women from 2008 to 2009 revealed that there were 166 cases (1.69%) of fetal choroid plexus cysts. Among them, 87 cases had chromosomal examination and the others were followed up until delivery. Results: Of the 166 cases with choroid cyst cyst, 92 cases were unilateral (55.42%), 74 cases were bilateral (44.58%), 40 cases were other ultrasound abnormalities (24.10%), including 7 cases of fetal structural malformations, Other ultrasound soft targets in 25 cases, other ultrasound abnormalities in 10 cases; found in 5 cases of chromosomal abnormalities were 18-trisomy; most of the choroid plexus cysts in 28 weeks before pregnancy disappeared. CONCLUSION: Fetal choroid plexus cysts are usually diagnosed by ultrasound during the second trimester, mainly related to 18-trisomy. Fetal choroid plexus cysts with good prognosis, if combined with other high-risk factors, such as fetal structural abnormalities, old age, bilateral multiple choroidal cysts, other ultrasound soft index, then the risk of chromosomal abnormalities significantly increased should be amniocentesis or cord blood puncture Surgery to clear the karyotype.