Celastrol alleviates arthritis by modulating the inflammatory activities of neutrophils

• 作 者: Kai Yuan Guangrui Huang Shan Z
• 机 构: SchoolofLifeSciences,StateKeyLaboratoryofBiocontrol
• 出 处: 中医科学杂志(英文)
• 发表日期: 2017年1期
• 关键词: RHEUMATOID ARTHRITIS NEUTROPHILS CELASTROL
• 基金项目: the National Natural Science Foundation of China(Grant number 81430099),International S&T Cooperation Program of China(Grant number 2014DFA32950),Beijing Municipal Commission of Education(Grant nu

Objective:Neutrophils play an important role in the pathogenesis of rheumatoid arthritis (RA).In this study,we used the adjuvant-induced arthritis murine model to evaluate the efficacy of celastrol on neutrophil-mediated inflammation in RA.Methods:Freund&