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Sulfasalazine(SAS)用于防治炎症性肠病(IBD)将近40年.一些文献复习表明口服SAS2-4g/d对轻、中型溃疡性结肠炎有效,且能预防复发,对结肠及回肠结肠部的克隆氏病(CD)也有作用,但不能预防复发,对局限于小肠的CD则效果不佳.SAS是磺胺吡啶与5-氨基水杨酸(5-ASA)由偶氮基连接而成,5-ASA是SAS的主要具活性的代谢产物,而磺胺吡啶则与大部分毒性作用有关.口服SAS后约75%到结肠,在该处释出5-ASA与磺胺吡啶.5-
Sulfasalazine (SAS) for the prevention and treatment of inflammatory bowel disease (IBD) for nearly 40 years.Some literature review shows that oral SAS2-4g / d of light and medium-sized ulcerative colitis effective and can prevent recurrence of colon and ileum Crohn’s disease (CD) also has an effect, but does not prevent relapse and does not respond well to CD confined to the small intestine.SAS is a combination of sulfapyridine and 5-aminosalicylic acid (5-ASA) -ASA is the major active metabolite of SAS while sulfapyridine is associated with most toxic effects Approximately 75% of oral administration of SAS to the colon where 5-ASA and sulfapyridine are released.5-