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目的研究胃癌组织趋化因子受体3(CCR3)的表达及临床意义。方法收集胃癌组织标本62例,采用FQ-PCR和免疫组化法检测胃癌癌组织、癌旁组织及正常胃组织中CCR3mRNA及蛋白表达,分析其病理临床意义。结果 62例中,胃癌癌组织CCR3mRNA及蛋白的表达量高于癌旁组织和正常胃组织(P<0.05);CCR3mRNA及蛋白的表达量与胃癌分化程度、淋巴结转移相关(P<0.01),与患者年龄、性别、肿瘤大小、肿瘤部位、肿瘤分期和浸润深度无关(P>0.05)。结论CCR3在胃癌癌组织中表达水平明显升高,并与胃癌分化程度及淋巴结转移密切相关;CCR3可成为临床治疗的潜在靶点。
Objective To study the expression of chemokine receptor 3 (CCR3) in gastric carcinoma and its clinical significance. Methods Tissue specimens of 62 cases of gastric cancer were collected. The expression of CCR3 mRNA and protein in gastric cancer tissues, adjacent non-cancerous tissues and normal gastric tissues were detected by FQ-PCR and immunohistochemistry, and their clinical significance was analyzed. Results The expression of CCR3 mRNA and protein in gastric cancer tissues was higher than that in paracancerous tissues and normal gastric tissues (P <0.05). The expression of CCR3 mRNA and protein was correlated with the differentiation and lymph node metastasis (P <0.01) The age, gender, tumor size, tumor location, tumor stage and depth of invasion had no relation (P> 0.05). Conclusion The expression of CCR3 in gastric cancer tissues is significantly increased, which is closely related to the differentiation of gastric cancer and lymph node metastasis. CCR3 may be a potential target for clinical treatment.