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核黄疸(kerbicterus),亦称为胆红素中毒性脑病(bilirubinintoxicationencephalopathy),是由于未结合胆红素(unconjugatedbililirubin,UCB)在脑细胞的沉积所引起的一种病变。血清胆红素>342μmol/L(20mg/dl)就有发生核黄疸的危险。本病严重威胁新生儿的生命和健康,病死率很高,约有50％-75％,患儿死于急性期,幸存者约75％-90％患有严重的神经系统后遗症,是人类听力障碍、视觉异常和智能落后的重要原因。因而,核黄疸的预防、诊断、治疗始终是全球儿科界关注的话题。
Kerbicterus, also known as bilirubin poisoning encephalopathy, is a disease caused by unconjugated bilirubin (UCB) deposition in brain cells. Serum bilirubin> 342μmol / L (20mg / dl) there is the risk of occurrence of kernicterus. This disease seriously threatens the life and health of the newborn. The mortality rate is very high, about 50% -75%. The children die in the acute phase. About 75% -90% of the survivors have severe neurological sequelae and are human hearing Obstacles, visual anomalies and intelligent backwardness of the important reasons. Therefore, the prevention, diagnosis and treatment of nuclear jaundice have always been the focus of the global pediatric community.