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在过去,对于晚期,不能手术切除,而又经过放疗的宫颈癌患者,没有有效的治疗方法。用过几种抗肿瘤药物,但无明显效益。曾单一使用环磷酰胺和氨甲喋呤,偶有肿瘤消退;联合使用环磷酰胺和氨甲喋呤,则相当成功。亦有人使用羟基脲合并放射,治疗晚期宫颈癌。更有人报告20例已扩散的宫颈癌患者,合并使用博来霉素和氨甲喋呤时,有60％的患者出现部分缓解。本文报告37例无法切除,又接受过放疗的宫颈鳞状上皮癌患者,采用三种化疗方案:①阿霉素;②中等剂量氨甲喋呤;③大剂量氨甲喋呤伴以甲酰
In the past, there was no effective treatment for patients with advanced cervical cancer who were not surgically resected and who underwent radiotherapy. Several anti-cancer drugs used, but no significant benefit. Once a single use of cyclophosphamide and methotrexate, occasional tumor regression; combination of cyclophosphamide and methotrexate, was quite successful. Some people use hydroxyurea combined with radiation, treatment of advanced cervical cancer. It was even reported in 20 cases of patients with cervical cancer have been spread, with bleomycin and methotrexate, 60% of patients with partial remission. This article reports 37 cases of unresectable and recurrent cervical squamous cell carcinoma patients treated with three chemotherapy: ① doxorubicin; ② moderate dose methotrexate; ③ high-dose methotrexate with formyl