论文部分内容阅读
采用放射免疫分析法测定２８例肺心病患者及１４例正常人血浆内皮素（ＥＴ）含量，并同时作动脉血气分析及测定部分患者肺血管阻力（ＰＶＲ）、心输出量（ＣＯ）。结果：肺心病组血浆ＥＴ明显高于正常人（Ｐ＜０．０１），急性期显著高于缓解期（Ｐ＜０．０１）。血浆ＥＴ与ｐＨ、ＰａＯ２呈显著负相关（Ｐ＜０．０１），与ＰＶＲ呈显著正相关（Ｐ＜０．０１），与ＣＯ是显著负相关（Ｐ＜０．０１）。提示；低氧血症和酸血症可能是刺激血浆ＥＴ升高、引起肺血管内皮功能紊乱的重要因素；ＥＴ在肺血管阻力增加、肺动脉高压形成的病理过程中有其重要的作用。
Radioimmunoassay was used to determine the plasma endothelin (ET) level in 28 patients with cor pulmonale and 14 healthy controls. The arterial blood gas analysis and the pulmonary vascular resistance (PVR) and cardiac output (CO) were also measured in some patients at the same time. Results: Plasma ET in patients with pulmonary heart disease was significantly higher than that in normal people (P <0.01), and acute phase was significantly higher than that in remission (P <0.01). There was a significant negative correlation between plasma ET and pH and PaO2 (P <0.01), a significant positive correlation with PVR (P <0.01) and a negative correlation with CO (P <0.01). It is suggested that hypoxemia and acidosis may be the important factors to stimulate the elevation of plasma ET and cause the dysfunction of pulmonary vascular endothelium. ET plays an important role in the pathological process of pulmonary vascular resistance and pulmonary hypertension.