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目的 观察拉西地平对原发性高血压(EH)的疗效及其对血浆内皮素(ET)、血管紧张素Ⅱ(AGT-Ⅱ)的影响.结果拉西地平(n=40)每日1次4～8mg,治疗4周,降低血压的显效率67.5%,总有效率92.5%;其中Ⅰ期、Ⅱ期的总有效率(100%和96.5%)明显高于Ⅲ期(33.3%);平均收缩压(SBP)、舒张压(DBP)和平均动脉压(MAP)分别下降23.8、19.7和22.7mmHg;24h动态血压监测(n=20)证实拉西地平可降低白昼和夜间的平均SBP、DBP和MAP(均p<0.01);同时降低血浆ET、AGT-Ⅱ水平.结论 拉西地平降压稳定、持久,剂量小,每日服用1次,耐受性良好.
Objective To observe the effect of lacidipine on essential hypertension (EH) and its effects on plasma endothelin (ET) and angiotensin Ⅱ (AGT-Ⅱ) .RESULTS Ralizidipine (n = 40) The total effective rate (100% and 96.5%) in stage Ⅰ and stage Ⅱ was significantly higher than that in stage Ⅲ (33.3%) after treatment for 4 ~ 8mg for 4 weeks, the effective rate of lowering blood pressure was 67.5% and the total effective rate was 92.5%. Mean systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) decreased by 23.8, 19.7 and 22.7 mmHg respectively. Ambulatory blood pressure monitoring (n = 20) at 24 hours confirmed that lacidipine decreased mean SBP, DBP and MAP (all p <0.01), meanwhile, the levels of plasma ET and AGT-II were decreased.CONCLUSION Lassiadipine is stable and long-lasting with a small dosage and taking once a day.