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抗孕激素RU486的应用已经开辟了不同的临床实践机会。RU486是第一个被认定用于流产的药物。其作用方式是通过与孕激素竞争受体。在不同的国家中,经过几年的大量临床和实验室研究,此药作为妊娠早期流产药的效力和安全性已得到了证实。单纯给与RU486,600mg/口服,妊娠不足9周的妇女有60～85%发生完全流产。10～20%还需手术处理(清官术)。而1～5%的病人妊娠未受到干扰。通过肌肉注射或阴道内使用少量前列腺素可以明显增加RU486的作用。在法国,最近已批准
The application of anti-progestin RU486 has opened up different clinical practice opportunities. RU486 is the first drug approved for miscarriage. Its mode of action is by competing with progesterone receptors. In several countries, the efficacy and safety of this drug as an abortion agent in early pregnancy has been demonstrated after years of extensive clinical and laboratory studies. Simple to give RU486, 600mg / orally, less than 9 weeks pregnant women have 60 ~ 85% complete abortion. 10 ~ 20% need surgery (clean government). 1% to 5% of the patients were not disturbed in pregnancy. The effect of RU486 can be significantly increased by intramuscular or intravaginal administration of small amounts of prostaglandins. In France, it has recently been approved