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Importance::LIM domain only 1 (n LMO1) gene polymorphisms were previously found to be implicated in the risk of several cancers. No available studies were performed regarding the predisposing effect of n LMO1 gene single nucleotide polymorphisms (SNPs) on central nervous system (CNS) tumor risk.n Objective::We aimed to determine whether the n LMO1 gene SNPs were associated with the risk of CNS tumor by applying a case-control study with 191 cases and 248 controls in China.n Methods::The contributions of n LMO1 gene SNPs to the risk of CNS tumor was evaluated by multinomial logistic regression.n Results::Based on the calculations of odds ratio (n OR) and 95% confidence interval (n CI), we failed to detect a significant relationship between each n LMO1 gene SNP (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and CNS tumor risk, respectively. A negative association was also found in the combined effects on these five SNPs and CNS tumor risk. The stratification analysis further demonstrated the individuals with rs204938 AG/GG genotype confer to increased risk of CNS tumor compared with those with an AA genotype in males (n OR: 1.74, 95% n CI: 1.01-2.98, n P = 0.046).n Interpretation::We concluded that n LMO1 gene SNPs may not strong enough to influence the risk of CNS tumor in Chinese children. More studies are required to verify this association.n “,”Importance::LIM domain only 1 (n LMO1) gene polymorphisms were previously found to be implicated in the risk of several cancers. No available studies were performed regarding the predisposing effect of n LMO1 gene single nucleotide polymorphisms (SNPs) on central nervous system (CNS) tumor risk.n Objective::We aimed to determine whether the n LMO1 gene SNPs were associated with the risk of CNS tumor by applying a case-control study with 191 cases and 248 controls in China.n Methods::The contributions of n LMO1 gene SNPs to the risk of CNS tumor was evaluated by multinomial logistic regression.n Results::Based on the calculations of odds ratio (n OR) and 95% confidence interval (n CI), we failed to detect a significant relationship between each n LMO1 gene SNP (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and CNS tumor risk, respectively. A negative association was also found in the combined effects on these five SNPs and CNS tumor risk. The stratification analysis further demonstrated the individuals with rs204938 AG/GG genotype confer to increased risk of CNS tumor compared with those with an AA genotype in males (n OR: 1.74, 95% n CI: 1.01-2.98, n P = 0.046).n Interpretation::We concluded that n LMO1 gene SNPs may not strong enough to influence the risk of CNS tumor in Chinese children. More studies are required to verify this association.n