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Objective: To investigate the possible effect of hyperprolactinaemia induced by HPL on oogenesis in female albino rats. Methods: The oestrus cycle of each rat was observed daily for 16 days at a regular interval of 24 hours including Sunday. Animals from each group were scarified 24 hr after last treatment (on 17th day) following the ethical procedure for histopathological examination ovaries were separated. Results: In our study we found that prolactin treatment at the dioestrous phase increased the number of apoptotic cells and significant changes in volume of corpus luteum and the number of steriodogenic cell per corpus luteum decreased and therefore resultant synthesis of oestrogen decreased. So, haloperidol possesses antioestrogenic activity which may be attributed to high serum prolactin levels induced by haloperidol in experimental animals. Conclusion: In this study intraperitoneall administration of haloperidol at doses of 1, 2 and 5 mg/kg/day for 16 days significantly produced hyperprolactinaemia in female albino rats as compared to control. Hyperprolactinaemia produced by haloperidol causes significant increase in periodicity of dioestrous phase and decreased the other phase significantly in a dose dependent manner.