抗生素对奥曲肽治疗食管静脉曲张出血的影响

• 作 者: 程鹏 徐之德 刘应柯 彭传辉
• 机 构: 解放军153中心医院消化科!河南郑州450065,解放军153中心医院消化科!河南郑州450065,解放军153中心医院消化科!河南郑州450065,解放军153中心医院消化科!河南郑州450065
• 出 处: 临床肝胆病杂志
• 发表日期: 2000年04期
• 关键词: 食管静脉曲张出血 抗生素 奥曲肽 一氧化氮

探讨抗生素对奥曲肽治疗食管静脉曲张出血 (EVB)的影响及其机理。 6 0例EVB患者 ,随机分 2组 ,分别给予奥曲肽、奥曲肽联合抗生素治疗。EVB患者 6、12、2 4小时止血率、治疗前后血清一氧化氮 (NO)含量 ,奥曲肽组分别为 2 7%、40 %、6 3%、( 6 .9± 0 .8) μmol/L、( 5 .6± 0 .9) μmol/L(P <0 .0 5 ) ;奥曲肽联合抗生素组分别为 5 0 %、70 %、93 %、( 7.3± 0 .6 ) μmol/L、( 4.3± 0 .7) μmol/L(P <0 .0 5 )。结论 :抗生素明显提高奥曲肽治疗EVB的疗效 ,其机理可能与降低血清NO含量有关。

To investigate the effect of antibiotics on the octreotide treatment of esophageal variceal bleeding (EVB) and its mechanism. Sixty patients with EVB were randomly divided into two groups, respectively, given octreotide, octreotide combined antibiotics. The hemostatic rate at 6, 12, and 24 hours was significantly higher in patients with EVB than those in patients with octreotide alone (27.7%, 40%, 63%, 6.9 ± 0.8 μmol / L, , (5 .6 ± 0. 9) μmol / L, respectively (P <0.05). The levels of octreotide and antibiotics were 50%, 70%, 93%, 7.3 ± 0.6 μmol / 4.3 ± 0 .7) μmol / L (P <0.05). Conclusion: Antibiotics can significantly improve the efficacy of octreotide in the treatment of EVB. The mechanism may be related to the decrease of serum NO level.