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细胞色素Ｐ45 0 (ＣｙｔｃｈｒｏｍｅＰ45 0 ,ＣＹＰ) ,是四氯化碳(ＣＣｌ4 )在体内进行代谢活化的主要酶类。研究表明 ,ＣＣｌ4 的活化产物 ,如·ＣＣｌ3 等对ＣＹＰ酶类本身也产生破坏作用 ,而不同亚型ＣＹＰ对于ＣＣｌ4 的破坏作用表现不同的敏感性 ,并且可能受到不同剂量不
Cytochrome P45 0 (CYP) is a major enzyme that metabolizes carbon tetrachloride (CCl4) in vivo. Studies have shown that the activation products of CCl4, such as · CCl3 also have a damaging effect on the CYP enzymes themselves, while the different subtypes of CYP show different sensitivity to the destruction of CCl4 and may be affected by different doses