论文部分内容阅读
结节性淋巴细胞为主型霍奇金淋巴瘤(NLPHL)与经典型霍奇金淋巴瘤(CHL)因其不同的临床和病理特征被独立进行分类。EBV在25%~70%的经典型霍奇金淋巴瘤中可以检测到,而在大多数结节性淋巴细胞为主型霍奇金淋巴瘤中却为阴性。本研究评估302例成人及儿童结节性淋巴瘤细胞为主型霍奇金淋巴瘤(选取北美3个医学中心的145例儿童(≤18岁)及157例成人),并复习其临床及病理特点,同时采用原位杂交方法检测肿瘤中的EBV小分子RNA(EBER)。其中5例(3.4%)儿童和7例(4.5%)成人结节性淋巴
Nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL) and classic Hodgkin lymphoma (CHL) are independently classified for their different clinical and pathological features. EBV is detectable in 25% to 70% of classic Hodgkin’s lymphoma, but negative in most of the nodal lymphocyte-predominant Hodgkin’s lymphoma. This study evaluated 302 adult and child nodular lymphoma-predominant Hodgkin lymphoma (145 children (≤18 years) and 157 adults in three North American centers of medicine) and reviewed their clinical and pathological features The EBV small molecule RNA (EBER) in tumor was detected by in situ hybridization. 5 (3.4%) children and 7 (4.5%) adult nodular lymphomas