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目的探讨川崎病(KD)及早期不典型川崎病的临床特征、实验室检查、冠状动脉(冠脉)损害的危险因素及治疗方法。方法对儿科2004年8月至2009年8月诊治的71例KD患儿的临床资料进行回顾性分析。结果 71例KD中典型43例,不典型28例。男41例,女30例,男女比例为1.37∶1。年龄9个月至13岁,<1岁3例,～3岁38例,～5岁17例,>5岁13例。平均发病年龄3岁9个月。早期误诊22例。合并冠脉损害者30例,均为冠脉扩张。结论典型KD早期易诊断,预后好,不易发生冠脉损害。不典型KD早期易误诊,易发生冠脉损害。KD发病10d内用丙种球蛋白(1g/kg)单次给药效果好,大部分患儿24h内热退。
Objective To investigate the clinical characteristics, laboratory tests and the risk factors of coronary artery (coronary artery) injury in patients with Kawasaki disease (KD) and early atypical Kawasaki disease. Methods The clinical data of 71 KD children diagnosed and treated from August 2004 to August 2009 were analyzed retrospectively. Results Among 71 KD cases, 43 were typical and 28 were not typical. There were 41 males and 30 females, with a male-female ratio of 1.37: 1. Aged 9 months to 13 years old, <1 year in 3 cases, ~ 3 years in 38 cases, ~ 5 years in 17 cases,> 5 years old in 13 cases. The average age of onset 3 years and 9 months. Early misdiagnosis in 22 cases. 30 cases of coronary artery lesions were coronary dilatation. Conclusion The early diagnosis of typical KD is easy to diagnose, the prognosis is good and coronary artery lesion is not easy to occur. KD atypical early misdiagnosis, prone to coronary artery lesions. Within 10 days of onset of KD, single administration of gamma globulin (1 g / kg) was effective, and most of the children returned with heat within 24 hours.