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目的评价小牛血清去蛋白注射液治疗缺血性脑卒中的经济性。方法计算机检索中国生物医学文献数据库、中国期刊全文数据库、中文期刊全文数据库和万方数据知识服务平台,收集在常规治疗基础上加用小牛血清去蛋白注射液或依达拉奉注射液治疗缺血性脑卒中的随机对照试验,利用间接比较的Meta分析对小牛血清去蛋白注射液(试验组)和依达拉奉注射液(对照组)治疗缺血性脑卒中的临床效果进行比较,根据Meta分析的结果选择成本-效果分析法或最小成本分析法,比较两者的经济性。结果本研究共纳入26篇文献,共计2765例患者。间接比较的Meta分析结果显示,试验组与对照组的临床效果无显著性差异[OR=0.83,95%CI(0.54,1.31)];最小成本分析结果显示,试验组与对照组的药物治疗费用分别为2391.76元和3761.24元,试验组与对照组费用差为1369.48元,试验组具有经济性。结论小牛血清去蛋白注射液对比依达拉奉注射液在治疗缺血性脑卒中方面更具有经济性,但仍需大样本、高质量研究对其临床效果进行进一步验证。
Objective To evaluate the economy of ischemic stroke with intravenous injection of bovine serum albumin. Methods We searched Chinese biomedical literature database, Chinese periodical full-text database, Chinese periodical full-text database and Wanfang data knowledge service platform. We collected the conventional treatment based on the addition of bovine serum deproteinized injection or edaravone injection Randomized controlled trials of bloody stroke, the indirect comparison of meta-analysis of bovine serum albumin dextran injection (experimental group) and edaravone injection (control group) for the treatment of ischemic stroke clinical efficacy were compared, According to the results of Meta analysis choose cost-effectiveness analysis method or the least cost analysis, compare the two economy. Results A total of 26 articles were included in this study for a total of 2,765 patients. Indirect comparison of meta-analysis showed no significant difference between the experimental group and the control group (OR = 0.83,95% CI (0.54,1.31)]; the minimum cost analysis showed that the treatment group and the control group of drug treatment costs Respectively, 2391.76 yuan and 3761.24 yuan, the experimental group and the control group cost difference of 1369.48 yuan, the experimental group with economy. Conclusion Compared with edaravone injection, the deproteinization of bovine serum is more economical in the treatment of ischemic stroke, but large samples and high quality studies are needed to further verify its clinical effect.