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本项研究利用免疫组织化学技术，通过对胃癌，尤其是其背景粘膜肠上皮化生的细胞增殖活性的研究，探讨了肠上皮化生与胃癌发生的相关性。结果发现，肠上皮化生主要出现在分化型癌周围，其增殖活性明显高于正常胃粘膜，尤其是高度肠上皮化生粘膜处于增殖亢进、增殖活性不稳定状态。细胞增殖动态研究结果提示肠上皮化生是胃癌多阶段发生中一个重要阶段。
In this study, immunohistochemistry was used to investigate the relationship between intestinal metaplasia and gastric cancer by studying the cell proliferation activity of gastric cancer, especially its intestinal mucosal metaplasia. The results showed that intestinal metaplasia occurred mainly around differentiated carcinomas, and its proliferation activity was significantly higher than that of normal gastric mucosa. In particular, highly intestinal metaplastic mucosa was hyperproliferative and proliferative activity was unstable. The results of cell proliferation dynamics suggest that intestinal metaplasia is an important stage in the multistage development of gastric cancer.