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目的评价浙江省2013—2014年疑似预防接种异常反应(AEFI)监测工作开展情况及疫苗安全性。方法收集国家AEFI监测系统浙江省2013—2014年报告的AEFI个案,采用描述性流行病学方法,结合监测方案相关指标进行分析评价。结果浙江省2013—2014年AEFI估算报告发生率为21.90/10万,通过AEFI监测系统共报告9 441例个案,男女性别比1.40∶1,报告县覆盖率达到100.00%,乡镇街道覆盖率均未超过80%,1岁以下儿童占总报告数的51.91%,5—8月报告较多。个案分类中一般反应占81.70%;异常反应占15.31%,异常反应中临床诊断以过敏性皮疹为主,异常反应报告个案数与报告发生率最高的疫苗均为麻疹-风疹联合减毒活疫苗(482例,29.67/10万)。结论浙江省2013—2014年AEFI监测敏感性进一步提高,异常反应发生率在预期范围内,疫苗接种安全有效,但地区间报告不平衡,报告质量有待进一步加强。
Objective To evaluate the safety of vaccines against suspected opportunistic immunization (AEFI) in Zhejiang Province from 2013 to 2014. Methods The AEFI cases reported by the national AEFI monitoring system in Zhejiang Province during 2013-2014 were collected and analyzed by using descriptive epidemiological method and the related indicators of the monitoring program. Results The incidence of AEFI in 2013-2014 in Zhejiang province was 21.90 / 100 000. A total of 9 441 cases were reported by the AEFI monitoring system. The male-to-female sex ratio was 1.40:1. The coverage rate of the reporting county reached 100.00% More than 80% of children under the age of 1 accounted for 51.91% of the total number of reports, from May to August more reports. In the case classification, 81.70% of the general reactions, 15.31% of the abnormal reactions, allergic reactions in the clinical diagnosis of allergic rash, the number of reported cases of anomalous reactions and the highest incidence of vaccines are measles - rubella combined attenuated live vaccine ( 482 cases, 29.67 / 100000). Conclusion The sensitivity of AEFI surveillance in 2013-2014 in Zhejiang province was further improved. The incidence of abnormal reaction was within the expected range. Vaccination was safe and effective. However, the inter-regional reporting was not balanced and the quality of the report needs to be further strengthened.