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目的 :探讨原发性高血压患者脑钠肽变化及其临床意义。方法 :用放射免疫分析 79例原发性高血压 (EH)患者和 4 9例非高血压患者的脑钠肽 (BNP)水平 ,并进行对照统计分析。结果 :EH组血清BNP水平显著高于对照组 (p <0 0 1 ) ,且与平均动脉压成显著正相关 (p <0 0 5 ) ,但与体重指数无相关性意义。Ⅰ、Ⅱ、Ⅲ期组间平均血清BNP水平依次显著性递增 (p <0 0 1 ) ,伴心脑血管并发症组显著高于无并发症组 (p <0 0 1 ) ,男女组间无统计学差异。结论 :EH患者血清BNP水平显著增高 ,且与平均动脉压、高血压分期及是否伴有并发症相关 ,提示BNP变化与病情严重程度相关。
Objective: To investigate the changes of brain natriuretic peptide in patients with essential hypertension and its clinical significance. Methods: The levels of BNP in 79 patients with essential hypertension (EH) and 49 non-hypertensive patients were analyzed by radioimmunoassay, and the control group was statistically analyzed. Results: Serum BNP level in EH group was significantly higher than that in control group (p <0.01), and was positively correlated with mean arterial pressure (p <0.05), but not with body mass index. The mean serum BNP levels in groups Ⅰ, Ⅱ and Ⅲ increased significantly (p <0.01), and were significantly higher in patients with cardio-cerebral vascular complications than those without complications (p <0.01) Statistical differences. Conclusion: Serum BNP levels in patients with EH are significantly higher than those in patients with EH, and are related to mean arterial pressure, hypertension stage and complications. It suggests that the change of BNP is related to the severity of illness.