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目的:观察药物流产后及时服用妈富隆的临床效果。方法:在上海市区3个临床中心共招纳600例因非意愿妊娠要求药物流产的早孕(<49 d)健康妇女,采用随机双盲对照的多中心临床研究。各中心门诊按药物流产常规接纳对象,口服米非司酮配伍米索前列醇,孕囊排出后随机分为A组和B组,于当日起每晚加服A或B药(外包装相似)1片,连服21 d,定期随访完全流产率、阴道出血时间、月经恢复情况等。结果:完全按医嘱执行并纳入资料分析的共414例,统计后揭秘A药为妈富隆(去氧孕烯炔雌醇片),209例,B药为安慰剂(不含任何药物的淀粉剂),205例,妈富隆组完全流产率高、月经恢复时间和经期出血时间短,与对照组比较差异均有统计学意义(P<0.05)。结论:药物流产后及时连续口服妈富隆21 d,能提高完全流产率,促进月经恢复,缩短流产后出血时间、转经时间和行经时间。
Objective: To observe the clinical effect of taking Marvelon after medical abortion. Methods: A total of 600 pregnant women (<49 days) who had medical abortion due to unplanned pregnancy were enrolled in three clinical centers in Shanghai. Randomized, double-blind, multicenter clinical studies were conducted. Outpatients were admitted to the center according to the medical abortion routine, and oral mifepristone and misoprostol were administered. The gestational sac was randomly divided into A group and B group. On the same day, A or B medicine was added every night (the packaging was similar) 1 tablet, and even served 21 d, regular follow-up complete abortion rate, vaginal bleeding time, menstrual recovery and so on. Results: A total of 414 cases were performed according to the doctor’s advice and included in the data analysis. Statistics revealed that the drug A was marvelon (desogestrel ethinyl estradiol tablets), and the drug B was placebo (starch without any drug ). In 205 cases, the rate of complete abortion in Marvelon group was high, the time of menstruation recovery and the bleeding time of menstrual period were short, which were significantly different from those in control group (P <0.05). CONCLUSION: Continuous oral administration of Marvelon for 21 d after abortion can increase the rate of complete abortion, promote the recovery of menstruation and shorten the bleeding time, menstrual cycle time and menstrual cycle time after abortion.