论文部分内容阅读
目的总结老年结直肠癌肝转移(CRCLM)治疗的现状,探讨老年CRCLM治疗的方法和原则。方法复习国内、外近年来有关老年CRCLM治疗的相关文献并作综述。结果结直肠癌是消化系统最常见的恶性肿瘤,而最常见的转移部位是肝脏。近年来,老年结直肠癌发病率逐渐升高。虽然同年轻患者比较,老年CRCLM患者的身体状态和生理机能较差,但只要选取合适的病例,同样可以获得与年轻患者相似的治疗效果。目前,对于可切除的CRCLM患者,惟一可能治愈的手段仍然是外科手术治疗;而化疗和分子靶向药物治疗的最新进展,也让更多的老年患者生存获益。对于不可切除的CRCLM病灶尚可结合其他肝脏导向的局部治疗方法,如局部化疗、消融治疗等。结论根据CRCLM的发病特点和老年患者的自身特点,采用多学科协作模式下的个体化治疗模式,可进一步提高老年CRCLM患者的综合治疗效果。
Objective To summarize the current situation of senile colorectal cancer liver metastasis (CRCLM) treatment and to explore the methods and principles of senile CRCLM treatment. Methods To review and summarize the literature about the treatment of senile CRCL at home and abroad in recent years. Results Colorectal cancer is the most common malignant tumor of the digestive system, and the most common site of metastasis is the liver. In recent years, the incidence of colorectal cancer in elderly gradually increased. Although elderly patients with CRCLM have poorer physical status and physiology than younger patients, similar treatment options can be obtained with younger patients as long as the appropriate patient is selected. Currently, the only possible cure for resectable patients with CRCLM remains surgical treatment, and the latest advances in chemotherapy and molecular targeted drug therapy benefit more elderly patients. For unresectable CRCLM lesions can be combined with other liver-oriented local therapies, such as local chemotherapy, ablation and so on. Conclusion According to the morbidity characteristics of CRCLM and the characteristics of elderly patients, the individualized treatment mode in multidisciplinary collaboration mode can further improve the comprehensive treatment effect of elderly patients with CRCLM.