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目的:探讨糖尿病患者发生微循环障碍时,外周神经病变(DPN)与视网膜病变之间是否有相关性,及二者在2型糖尿病中的危险指数。方法:本研究包括100例(男性51例,女性49例)门诊的糖尿病患者,均为非胰岛素依赖的糖尿病患者(NIDDM),观察患者的外周神经病变及视网膜病变进展情况,随访时间18mo。结果:视网膜病变的患者78.1%同时有外周神经病变,患有外周神经病变的患者79.1%同时有视网膜病变,统计学分析表明外周神经病变与视网膜病变之间并没有明显的相关性。但是,90.9%患有增殖性糖尿病视网膜病变的患者同时有外周神经病变,而27.8%患有视网膜病变的患者同时有外周神经病变,单因素及多因素logistic回归分析均表明它们之间有明显的相关性(r=0.42,P=0.02)。结论:严重的糖尿病视网膜病变与糖尿病性神经病变有相关性。本研究表明糖尿病神经病变可作为糖尿病视网膜病变进程的预警信号,出现神经病变的患者需要更细致广泛的眼科检查,特别是对于病程较长的糖尿病患者。
Objective: To investigate the correlation between peripheral neuropathy (DPN) and retinopathy and the risk index of type 2 diabetes mellitus in patients with microcirculation. Methods: This study consisted of 100 outpatients with diabetes mellitus (51 males and 49 females) with non-insulin dependent diabetes mellitus (NIDDM). Peripheral neuropathy and retinopathy were observed. The follow-up time was 18 months. Results: 78.1% of patients with retinopathy also had peripheral neuropathy. 79.1% of patients with peripheral neuropathy also had retinopathy. Statistical analysis showed no significant correlation between peripheral neuropathy and retinopathy. However, 90.9% of patients with proliferative diabetic retinopathy also had peripheral neuropathy, while 27.8% of patients with retinopathy also had peripheral neuropathy. Univariate and multivariate logistic regression analysis showed that there was significant Correlation (r = 0.42, P = 0.02). Conclusions: Serious diabetic retinopathy is associated with diabetic neuropathy. This study shows that diabetic neuropathy can serve as an early warning signal for the progression of diabetic retinopathy. Patients with neuropathy require more extensive and extensive eye exams, especially for patients with longer duration of diabetes.