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金硫葡萄糖(GTG)、汞硫葡萄糖均可用于制作下丘脑损伤性肥胖动物模型,而钠硫葡萄糖则可对抗GTG对下丘脑腹内侧核的破坏,故不宜使用。GTG肥胖鼠,小肠对葡萄糖(G)吸收率加快其原因可能与肥胖伴有血糖改变及胰岛素升高有关。整体实验四氧嘧啶糖尿病鼠小肠对G吸收率降低,用胰岛素治疗G吸收增加的现象,在离体小肠吸收G实验中未观察到,故肥胖高胰岛素可能通过改变血糖水平继发性影响G吸收。 谷氨酸一钠虽也可以引起大鼠腹股沟脂肪垫增长,但常伴活的过度及视网膜损害,故不宜用于制作肥胖模型。胰岛素小量多次注射可以刺激食欲使进食量增加,体重增长,肌肉增多。
Gold sulphur glucose (GTG), mercury-sulfur glucose can be used to make animal models of hypothalamic injury, and sodium sulphur and glucose can prevent GTG damage to the ventromedial hypothalamic nucleus, so it should not be used. In GTG-obese mice, the rapid uptake of glucose (G) in the small intestine may be related to obesity accompanied by changes in blood glucose and elevated insulin levels. The overall experimental alloxan-induced diabetic mice have reduced G absorption rate in the small intestine, and the increase in absorption of G by insulin treatment was not observed in isolated small intestinal gavage G experiments. Therefore, high insulin may influence G absorption by changing blood glucose levels. . Although monosodium glutamate can also cause growth of rat inguinal fat pads, it is often accompanied by excessive live and retinal damage, so it should not be used to make obese models. A small number of insulin injections can stimulate appetite, increase food intake, increase body weight, and increase muscle mass.