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关于缺氧性肺血管收缩(HPV)发病机理的研究以往多集中在能引起HPV的介质方面。近年来有证据据示内源性扩管物质如内皮细胞源性松驰因子(EDRF)的改变可能与HPV的发病机理有关。目前不少文献认为一氧化氮(NO)即为EDRF。本文探讨了特异性的NO生成抑制剂L-精氨酸甲酯(L-NAME)和L-精氨酸苯甲酯
Research on the pathogenesis of hypoxic pulmonary vasoconstriction (HPV) has traditionally focused on the mediators that cause HPV. In recent years there is evidence that changes in endogenous materials such as endothelium-derived relaxation factor (EDRF) may be related to the pathogenesis of HPV. At present, many literatures think that nitric oxide (NO) is EDRF. This article explored the specific NO production inhibitors L-arginine methyl ester (L-NAME) and L-arginine benzyl ester