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目的 探讨增殖细胞核抗原 (PCNA)在不同分化程度的食管癌中的表达及其与生存期的关系。方法 用S -P免疫组化法研究 5 4例食管癌PCNA的表达情况。结果 PCNA表达与 1a、3a、5a生存期之间无统计学意义。组织分化程度 (Ⅰ～Ⅲ )与PCNA表达 (+～ )有正相关系存在 (r =0 .46 77) ,且有显著性差异 (P <0 .0 5 )。结论 PCNA是反映肿瘤细胞分化程度的客观指标之一 ,但对食管癌的生存期意义不大
Objective To investigate the expression of proliferating cell nuclear antigen (PCNA) in different degrees of esophageal cancer and its relationship with survival. Methods S-P immunohistochemistry was used to study the expression of PCNA in 54 cases of esophageal cancer. Results There was no significant difference between the expression of PCNA and the survival of 1a, 3a and 5a. There was a positive correlation between the degree of tissue differentiation (I~III) and PCNA expression (+~) (r = 0.447 77), and there was a significant difference (P < 0.05). Conclusion PCNA is one of the objective indicators to reflect the differentiation of tumor cells, but it has little significance for the survival of esophageal cancer.