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目的探讨甲氨蝶呤联合米非司酮治疗异位妊娠的临床疗效。方法将我院收治的异位妊娠患者92例随机分为对照组和观察组,其中对照组45例,给予甲氨蝶呤治疗方案;观察组47例,给予甲氨蝶呤联合米非司酮治疗方案。疗程结束后评价两组患者总有效率和β-HCG下降(接近)至正常所需时间以及不良反应发生情况。结果治疗后,与对照组相比较,观察组总有效率和β-HCG下降至(接近)正常所需时间均有显著性的提升(P<0.05),而不良反应发生情况无差异(P>0.05)。结论甲氨蝶呤联合米非司酮治疗异位妊娠疗效确切,安全有效,是临床保守治疗异位妊娠的较好方法,适于临床中推广应用。
Objective To investigate the clinical efficacy of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods 92 cases of ectopic pregnancy admitted to our hospital were randomly divided into control group and observation group, of which 45 cases in control group were given methotrexate treatment program; observation group 47 cases, given methotrexate combined with mifepristone Treatment programs. At the end of the course of treatment, the total effective rate and the decline in (decreased) β-HCG to normal time and the adverse reactions were evaluated. Results Compared with the control group, the total effective rate and the time required for β-HCG to decrease (close to normal) were significantly increased after treatment (P <0.05), while the incidence of adverse reactions was no significant difference (P> 0.05). Conclusion Methotrexate combined with mifepristone treatment of ectopic pregnancy exact, safe and effective clinical conservative treatment of ectopic pregnancy is a better method for clinical application.