论文部分内容阅读
目的:探讨无创正压通气(NIPPV)治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭的疗效。方法:70例AECOPD合并Ⅱ型呼吸衰竭患者随机分为对照组和试验组。在常规治疗的基础上,对照组予低流量吸氧(2L/min),试验组接受呼吸机无创通气治疗。于治疗前、治疗后5天,分别记录动脉血气指标(pH、PaCO2、PaO2)、肺功能(FEV1/FVC%、RV/TLC%、DLCO%)。结果:两组患者在治疗前在年龄、病程、血气分析及肺功能等方面无明显差异。两组患者治疗前后动脉血气检测及肺功能(RV/TLC%、DLCO%)结果及治疗后组间比较差异有显著性(P<0.05),但两组肺功能FEV1/FVC%治疗前后及组间比较无显著性差异,两组插管率比较差异有显著性(P<0.05)。结论:无创通气是治疗慢性阻塞性肺疾病急性加重期并发Ⅱ型呼吸衰竭的一种有效方法。早期使用能阻止病情的发展,缓解临床症状,降低气管插管率。
Objective: To investigate the efficacy of noninvasive positive pressure ventilation (NIPPV) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with respiratory failure. Methods: Seventy patients with AECOPD and type Ⅱ respiratory failure were randomly divided into control group and experimental group. On the basis of routine treatment, the control group was given low-flow oxygen (2L / min), and the experimental group received ventilator noninvasive ventilation. Arterial blood gas parameters (pH, PaCO2, PaO2), pulmonary function (FEV1 / FVC%, RV / TLC%, DLCO%) were recorded before treatment and 5 days after the treatment. Results: Before treatment, there was no significant difference between the two groups in terms of age, course of disease, blood gas analysis and pulmonary function. The results of arterial blood gas test and pulmonary function (RV / TLC%, DLCO%) before and after treatment in both groups showed significant difference (P <0.05), but both groups before and after FEV1 / FVC% treatment There was no significant difference between the two groups intubation rate was significantly different (P <0.05). Conclusion: Noninvasive ventilation is an effective method for the treatment of type Ⅱ respiratory failure in acute exacerbation of chronic obstructive pulmonary disease. Early use can prevent the development of the disease, relieve clinical symptoms and reduce the rate of tracheal intubation.