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利用靜脉注射Rb~(86)Cl后,从其血液稀釋曲綫計算心输出量,并从各器官的分布百分率計算其血流量。本文改进用心电图紙代替分段收集器收集血液,特別适用于小动物实驗。 (一)正常鼠連續两次测定,間隔10分钟,其心脏血流动力作用无改变。說明Rb~(86)及实驗过程(如放血等)对大鼠的心血管功能干扰不大。 (二)靜脉注射腎上腺素(2微克)后,血压升高,心輸出量及作功量增加非常显著,同时增加心肌、肝、肺及腎血流量,除脾血管阻力增大外,对其他部位血管阻力影响不大。去甲腎上腺素(2微克)明显增加总外周血管阻力,对心輸出量增加較少,也增加心肌、肺、肝血流量,但对腎及脾血流量影响較少。
After intravenous injection of Rb (86) Cl, the cardiac output was calculated from the hemodilution curve and the blood flow was calculated from the distribution percentage of each organ. This paper improves the use of electrocardiogram instead of segmented collectors to collect blood, especially for small animal experiments. (A) normal rats measured twice in a row, 10 minutes intervals, the cardiac hemodynamic effects of no change. Rb ~ (86) and the experimental process (such as bleeding, etc.) on the cardiovascular function of rats is not disturbed. (B) intravenous injection of epinephrine (2 micrograms), the blood pressure, cardiac output and work volume increased significantly, while increasing myocardial, liver, lung and renal blood flow, in addition to increased splenic vascular resistance, the other The site of vascular resistance has little effect. Norepinephrine (2 micrograms) significantly increased total peripheral vascular resistance with less cardiac output, increased myocardial, pulmonary and hepatic blood flow but had less effect on renal and splenic blood flow.