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目的 :探讨 E- cadherin、CD4 4 - H和 VEGF基因的表达与鼻咽癌复发的关系。方法 :应用免疫组化 SP法检测6 2例鼻咽癌组织中 E- cadherin、CD4 4 - H和 VEGF的表达。结果 :在鼻咽癌放疗后复发组中 ,E- cadherin的表达减弱 ,CD4 4 - H和 VEGF的表达增强 ,与无复发组的表达差异有显著性 ,CD4 4 - H与 VEGF在鼻咽癌放疗后复发组中的表达有正相关关系。结论 :E- cadherin、CD4 4 - H和 VEGF的表达均与鼻咽癌放疗后复发的关系密切 ,CD4 4 - H和 VEGF存在协同作用 ,它们可作为评估鼻咽癌患者复发风险的生物学标志
Objective: To investigate the relationship between the expression of E - cadherin, CD4 4 - H and VEGF and the recurrence of nasopharyngeal carcinoma. Methods: The expressions of E - cadherin, CD4 4 - H and VEGF in 62 cases of nasopharyngeal carcinoma were detected by immunohistochemical SP method. Results: The expression of E - cadherin, the expression of CD4 4 - H and VEGF in nasopharyngeal carcinoma recurrence group were significantly lower than those in non - recurrence group. The expression of CD4 4 - H and VEGF in nasopharyngeal carcinoma The recurrence group after radiotherapy has a positive correlation between the expression. Conclusion: The expressions of E - cadherin, CD4 4 - H and VEGF are closely related to the recurrence of nasopharyngeal carcinoma after radiotherapy. CD4 4 - H and VEGF have synergistic effects and they can be used as biomarkers to evaluate the risk of recurrent nasopharyngeal carcinoma