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近来临床试验证实,钙拮抗剂具有控制动脉粥样硬化(动粥)病变发展的效应。此发现具有重大的现实和长远意义。它不仅是增加了钙拮抗剂的治疗用途,而且可能为寻找高效抗动粥药物开辟新的研究途径。现在需要明确的两个主要问题是:钙拮抗剂抗动粥作用是否与电压闸门的钙通道有关;其作用是单一的还是多种方式。钙耗竭剂如La~(3+)、EDTA、噻吩羧酸等能阻止实验性动粥病变的形成。另外,动粥
Recent clinical trials confirm that calcium antagonists have the effect of controlling the development of atherosclerotic lesions. This discovery has great realistic and long-term significance. It not only increases the therapeutic use of calcium antagonists, but also opens up new avenues for finding effective anti-porridge drugs. Now need to be clear two main questions are: calcium antagonist anti-porridge effect is related to the voltage gate of the calcium channel; its role is single or multiple ways. Calcium depletion agents such as La ~ (3 +), EDTA, thiophene carboxylic acid can prevent the formation of experimental porridge disease. In addition, moving porridge