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1988年Niijima等曾报道,大鼠呕吐时其迷走神经胃支传出活动减弱。此次以大鼠迷走神经胃支传出活动为指标,通过评价半夏的脂溶性组分和水溶性组分对神经活动的影响。探讨了半夏的止吐作用。实验动物为Wistar系雄性大鼠(体重300g左右),于实验前一日断食。半夏经甲醇提取后,残渣再用水提取。将大鼠在乌拉坦麻醉下(1g/kg,腹腔给药)开腹,经十二指肠插管给药,切断左侧
In 1988, Niijima et al. reported that the vagus nerve’s gastric branch was attenuated when rats vomited. The activity of rat vagus nerve stomach branch was used as an index to evaluate the effects of the components of Pinellia ternate and water-soluble components on nerve activity. The antiemetic effect of Pinellia was discussed. The experimental animals were Wistar male rats (about 300 g in body weight) and were fasted on the day before the experiment. After extraction with methanol in Pinellia, the residue was extracted with water. Rats underwent anesthesia under urethane anesthesia (1 g/kg, intraperitoneal administration) and were administered via duodenal cannulation, cutting off the left side