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目的:探讨雌激素在整体水平下的抗肾上腺素心律失常作用及可能机制。方法:24只新西兰大白兔随机分为对照组、利多卡因组及雌激素组,各组同步记录体表心电图及经左心室插管测定心功能指标[左心室内压 (LVSP)、左心室舒张终末压(LVEDP)、左心室内压最大上升速率(+dp/dtmax)、左心室内压最大下降速率(-dp/ dtmax)],比较各组按75μg/kg静脉注射0．1％肾上腺素前后心电图及相应心功能指标变化。结果:快速静脉注射肾上腺素可引起心功能指标明显上升,同时由于自律性增高致室性心律失常;雌激素可拮抗肾上腺素所致心功能改变,并延长室早(VP)出现时间,缩短室速(VT)持续时间及心律失常持续时间,其作用优于利多卡因(P< 0．05)。结论:雌激素对心律失常有一定对抗作用,可能与Ca2+阻断及改变细胞膜离子通透性有关。
Objective: To investigate the anti-adrenergic arrhythmia effect of estrogen at the whole level and its possible mechanism. Methods: Twenty-four New Zealand white rabbits were randomly divided into control group, lidocaine group and estrogen group. Each group was recorded on the surface electrocardiogram (ECG) and left ventricular intubation (left ventricular pressure (LVSP) LVEDP, + dp / dtmax and -dp / dtmax, respectively]. The rats in each group were given intravenous injection of 0.1% Changes of electrocardiogram and corresponding cardiac function before and after epinephrine. Results: Rapid intravenous injection of epinephrine can cause cardiac function increased significantly, at the same time due to self-discipline increased ventricular arrhythmia; estrogen can antagonize the epinephrine caused by changes in cardiac function, and to extend the early onset of ventricular (VP), shortening the room Duration of VT and duration of arrhythmia were superior to lidocaine (P <0.05). Conclusion: Estrogen can antagonize cardiac arrhythmia and may be related to the block of Ca2 + and the change of ion permeability of cell membrane.