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目的观察福辛普利对急性心肌梗死患者脑钠肽及左心室功能的影响并探讨其机制。方法入选急性心肌梗死患者88例分为贝那普利治疗组(47例)、对照组(41例)。所有患者均测定入院后第1、7及30d血浆BNP浓度,并于心梗后7d及30d行超声心动图检查左室舒张末期内径(EDD)及左室射血分数(LVEF)。结果两组在治疗后第7、30天BNP与EDD发现明显差异,BNP始终与LVEF呈现明显负相关,治疗组第30d时EDD显著下降(P<0.05)、LVEF显著增加(P<0.05)。结论急性心肌梗死后BNP水平升高并且与左心室功能呈负相关,贝那普利可以降低BNP水平,改善左心室功能。
Objective To observe the effect of fosinopril on brain natriuretic peptide and left ventricular function in patients with acute myocardial infarction and to explore its mechanism. Methods 88 patients with acute myocardial infarction were divided into benazepril treatment group (n = 47) and control group (n = 41). All patients were measured plasma BNP concentrations at 1, 7 and 30 days after admission. The left ventricular end-diastolic diameter (EDD) and left ventricular ejection fraction (LVEF) were measured by echocardiography at 7 days and 30 days after myocardial infarction. Results There was a significant difference between the two groups on the 7th and the 30th day after treatment. There was a significant negative correlation between BNP and LVEF. EDD was significantly decreased (P <0.05) and LVEF was significantly increased at the 30th day (P <0.05). Conclusions BNP levels are elevated after acute myocardial infarction and are negatively correlated with left ventricular function. Berenipril can reduce BNP level and improve left ventricular function.