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为研究尼莫通静脉滴往速度对血压和心率的影响,应用尼莫通10mg(即50ml)静脉滴注治疗36例蛛网膜下腔出血和缺血性卒中。按照滴注速度分成二组:常规组计106例次,其滴注速度为0.5~1.0mg(2.5~5.0ml)·小时-1;非常规组计54例次,满注速度为1.3~1.6mg(6.33~8.25ml)·小时-1。比较两组对血压、心率的影响,前者为正常或轻度变化,而后者绝大多数为中度以上的变化。经分组t检验有明显差异(P值<0.05)。结果证明:尼莫通对血压、心率的影响是剂量效应,常规滴注对血压和心率无明显影响;而尼莫通满注速度的不同可以应用于不同的临床目的。
In order to study the effect of nimotone intravenous infusion on blood pressure and heart rate, 36 cases of subarachnoid hemorrhage and ischemic stroke were treated with nimotop 10 mg (50 ml) intravenously. According to the infusion rate divided into two groups: the conventional group of 106 cases, the infusion rate of 0.5 ~ 1.0mg (2.5 ~ 5.0ml) · hour -1; unconventional group of 54 cases, full The injection rate is 1.3 to 1.6 mg (6.33 to 8.25 ml) · hr -1. Compare the two groups of blood pressure, heart rate, the former is normal or mild changes, while the latter for the vast majority of moderate changes. Subgroup t test showed significant differences (P value <0.05). The results showed that the effect of nimotop on blood pressure and heart rate was dose-effect. Conventional instillation had no significant effect on blood pressure and heart rate. However, the difference of nimoton-full infusion rate could be used for different clinical purposes.