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目的分析孕妇血清中IgG型抗-A/抗-B抗体效价与母婴血型不合引起的ABO新生儿溶血病(Haemolytic diseaseof the newborn,HDN)发生率的相关性,为HDN的早期诊断和预防提供依据。方法对2005～2008年广州市番禺区各医院送检的1 425份标本和花都区人民医院送检的300份标本(孕妇血型为O型,丈夫为非O型)进行IgG型抗-A/抗-B效价测定,并追踪新生儿HDN的发生情况,分析二者的相关性。结果 1 725份标本抗体筛选试验均未检出同种特异性血型免疫抗体;IgG型抗-A/抗-B抗体效价在16以上的有334份样本,其中有146例于产后1～3 d发生HDN,HDN的发生率随着孕妇IgG型抗-A/抗-B抗体效价的上升而升高,也有个别孕妇IgG型抗-A/抗-B抗体效价高达1 024,但新生儿未发生HDN。结论广州市番禺区和花都区孕妇血清中IgG型抗-A/抗-B抗体效价与HDN的发生密切相关,产前进行IgG型抗-A/抗-B抗体效价测定可预先判断HDN的发生。
Objective To analyze the correlation between the IgG anti-A / anti-B antibody titer in pregnant women and the incidence of neonatal hemolytic disease of the newborn (ABN) caused by maternal and neonatal blood group incompatibility, so as to provide early diagnosis and prevention of HDN Provide evidence. Methods A total of 1 425 specimens from hospitals in Panyu District of Guangzhou City from 2005 to 2008 and 300 specimens from Huadu District People’s Hospital (blood type of O pregnant women and non-O type of husband) were collected for IgG anti-A / Anti-B titer determination, and tracking the incidence of neonatal HDN, analysis of the correlation between the two. Results None of the 1 725 antibody screening tests detected the same type of specific immunoglobulin. The IgG titer of anti-A / anti-B antibody was 334 or more, of which 146 were postpartum 1 to 3 d occurred HDN, HDN incidence with the increase in pregnant women IgG type anti-A / anti-B antibody titers increased, there are individual pregnant women IgG anti-A / anti-B antibody titers up to 1 024, but freshmen No HDN occurred in children. Conclusion The titer of IgG anti-A / anti-B antibody in serum of pregnant women in Panyu District and Huadu District of Guangzhou City is closely related to the occurrence of HDN. Prenatal anti-A / anti-B IgG antibody titer can be pre-determined HDN happened.