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杂种犬43只,参照体重随机分为失血性休克人参预治疗组(HSG),失血性休克地塞米松预治疗组(HSD),各14只,其余15只为失血性休克组(HS)组。HSG组静脉注射人参二醇组皂甙溶液25mg/kg。HSD组肌注地塞米松1mg/kg,均于放血前1h给药。经颈动脉放血使平均动脉压降至5.3kPa,观察5h。结果表明,5h存活率,HSG组为92.9％,HSD组为76.9％(其中2只死于胃肠道弥漫性出血),HS组为66.7％;血浆血管紧张素Ⅱ(AⅡ)含量的变化显示,地塞米松和人参二醇组皂甙抑制失血后AⅡ含量的增高;血清去甲肾上腺素(NE)的测定结果表明,人参二醇组皂武和地塞米松可阻止失血性休克时血清NE含量的持续增高。
Thirty-four Mongrel dogs were randomly divided into the hemorrhagic shock ginseng pretreatment group (HSG), hemorrhagic shock dexamethasone pretreatment group (HSD), 14 in each, and the remaining 15 were hemorrhagic shock group (HS) groups. . The HSG group was intravenously injected with the panaxdiol saponin solution 25 mg/kg. Intramuscular injection of dexamethasone 1 mg/kg was administered to the HSD group at 1 hour before exsanguination. The carotid arterial blood pressure dropped the mean arterial pressure to 5.3 kPa and observed 5 h. The results showed that the 5-hour survival rate was 92.9% in the HSG group, 76.9% in the HSD group (2 of them died of diffuse bleeding in the gastrointestinal tract), 66.7% in the HS group, and changes in plasma levels of angiotensin II (AII). , Dexamethasone and Panaxadiol saponins inhibited the increase of AII after blood loss; Serum norepinephrine (NE) test results showed that panaxadiol dexamethasone and dexamethasone prevented serum NE content in hemorrhagic shock. The continued increase.