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抗结核药物所致肝损害临床较为常见,文献报道的出现可逆性中度转氨酶升高的比例为15％～30％,黄疸发生率多为1％～2％。尤其用异烟肼、利福平和吡嗪酰胺联合使用的化疗方案是目前治疗初治结核病患者的有效短程方案,但这三种药物均对肝功能有一定损害,可导致药物性肝炎,甚至引起致命的急性肝坏死并肝功能衰竭。本文收集呼伦贝尔市结核病防治院1992～2002年住院结核病人中因抗结核药物所致肝损害的254例患者进行
Anti-TB drug-induced liver damage is relatively common in the literature reported reversible moderate transaminase increased in the ratio of 15% to 30%, jaundice incidence of mostly 1% to 2%. Chemotherapy regimens, especially with isoniazid, rifampicin, and pyrazinamide, are currently effective short-term regimens for the treatment of newly diagnosed TB patients, but all three of these drugs have some effect on liver function and can lead to drug-induced hepatitis and even cause Deadly acute liver necrosis and liver failure. This collection of Hulun Buir City Tuberculosis Prevention and Treatment Hospital from 1992 to 2002 hospitalized tuberculosis patients due to anti-TB drug-induced liver damage in 254 patients