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目的了解药品不良反应(ADR)发生的特点与规律,促进临床合理用药。方法对我院2011年收集的200例ADR报告,分别从患者性别、年龄、所用药物、引发ADR的药品种类、ADR涉及的系统及临床表现等进行统计分析。结果从性别看,200例报告中男性患者数量大于女性患者数量,性别比例无明显差异。从年龄看,60岁以上患者ADR发生高于其他年龄段。从药物分类看,循环系统药物引发ADR的比例最高,其次,抗菌药物引发ADR的比例也较高。从ADR发生的临床表现看,以皮疹、瘙痒等皮肤及其附件损害为主。结论老年人在用药过程中发生的ADR概率较大,不可忽视;他汀类药物及中成药注射剂不良反应不可忽视;临床药师在ADR监测过程中发挥重要的作用;注重新的ADR的收集,对临床合理用药参考意义较大。
Objective To understand the characteristics and rules of adverse drug reaction (ADR) and to promote rational drug use in clinic. Methods A total of 200 ADR cases collected in our hospital in 2011 were analyzed statistically according to patient’s gender, age, drug used, the type of drug causing ADR, the system and clinical manifestation involved in ADR. Results According to gender, the number of male patients in 200 cases was greater than the number of female patients, with no significant difference in sex ratio. From the age of view, ADR occurred in patients over the age of 60 higher than other age groups. According to the classification of drugs, circulatory system drugs lead to the highest proportion of ADRs, and secondly, the proportion of anti-bacterial drugs that cause ADRs is also high. From the clinical manifestations of ADR to see, rash, itching and other skin damage and its accessories based. Conclusion The incidence of ADR in the elderly is high and can not be ignored. The adverse reactions of statins and proprietary Chinese medicines can not be neglected. Clinical pharmacists play an important role in the monitoring of ADR. Focusing on the collection of new ADRs, Rational use of medicine is of great significance.