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Background The socio-economic burden of acute exacerbation of chronic obstructive pulmonary disease(AECoPD)in Beijing is not fully understood.The study investigated the hospitalization cost in patients with AECOPD and the associated factors.Methods A multi-center,retrospective study was conducted jn the four hospitals in Beijing including two level Ⅲ hospitals and two level Ⅱ hospitals.Patients with AECOPD admixed to the hospitals between January and December in 2006 were enrolled.The hosDitalization cost and its relationship with disease severity and treatment were analyzed.Results Totally 439 patients were enrolled with 294 men(67.0%)and a mean age 73.4 years.The mean hospital stay was 20.7 days.A total of 204 patients(46.5%)had respiratory failure,153(34.9%)with cor pulmonale,123(28.0%)with coronary artery disease,231(52.6%) with hypertension,70(15.9%)with cerebrovascuIar disease and 32(7.3%)with renal failure.The percentage of drug cost to total cost was the highest(71.2%),followed by laboratory cost(16.7%),therapy cost(9.7%),oxygen cost(7.3%),radiology cost(4.5%),examination cost(4.5%),bed cost(4.1%).Correlation analysis showed that cost was positively correlated with age,hospitalization days,co-morbidities such as respiratory failure and cor pulmonale,hypertension.Three hundred and twenty-one patients were further analyzed.The hospitalization cost increased in patients with non-invasive ventilation(P＜0.01),invasive mechanical ventilation(P＜0.01),ICU stay(P＜0.01),antibiotics(P＜0.05),systemic steroids(P＜0.01),and poor prognosis(P＜0.05).Correlation analysis showed that the hospitalization cost was negatively correlated with percentage forced expiratory volume in 1 second (FEV1%)(r=0.149,P＜0.05),Ph(r=-0.258,P＜0.01),and PaO2(r=-0.131,P＜0.05),positively correlated with PaCO2 (r=0.319,P＜0.01),non-invasive positive pressure ventilation(r=0.375,P＜0.01)and duration(r=0.463,P＜0.01),invasive mechanical ventilation(r=0.416,P＜0.01)and duration(r=0.511,P＜0.01),ICU stay(r=0.390,P＜0.01)and duration (r=0.650,P＜0.01),antibiotics(r=0.140,P＜0.05)and systemic steroids(r=0.202,P＜0.01).Conclusions AECOPD had a great impact on healthcare resources utilization.Disease severity,use of non-invasive or invasive ventilation,ICU stay and usage of antibiotics and systemic steroids were the major determinants of hospitalization cost.Long-term regular treatment aimed at reducing the frequency of acute exacerbation will lower the social and economic burden of chronic obstructive pulmonary disease (COPD).