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以邻苯二酚为原料,通过酯化和Fries重排反应,合成了3,4-二羟基苯乙酮,然后在室温下,甲醇介质中,3,4-二羟基苯乙酮与吡咯在甲磺酸催化下缩合生成新化合物meso-四甲基-四(3,4-二羟基苯基)杯[4]吡咯,产率为20.5%。目标产物的结构通过核磁共振谱和元素分析确定。
Using catechol as raw material, 3,4-dihydroxyacetophenone was synthesized by esterification and Fries rearrangement reaction. Then, 3,4-dihydroxyacetophenone was reacted with pyrrole in methanol medium at room temperature The meso-tetramethyl-tetrakis (3,4-dihydroxyphenyl) calix [4] pyrrole was synthesized by methanesulfonic acid catalyzed condensation. The yield was 20.5%. The structure of the target product is confirmed by nuclear magnetic resonance spectroscopy and elemental analysis.