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目的研究塞隆骨替代豹骨后再造丸急性毒性及长期毒性。方法应用最大耐受量(MTD)测定法,对塞隆骨替代豹骨后再造丸进行小鼠急性毒性实验;大鼠长期毒性实验采用连续26周灌胃给药,分别于13周和26周每组处死10只和20只动物,其余动物停药进行恢复期观察4周,观察大鼠饮食、活动、体重、进食量、外观体征等情况,并进行血液、生化、病理学等检查。结果急性毒性实验未见动物死亡,MTD为20 g/kg,相当于人临床剂量(0.128 g/kg)的156倍;长期毒性实验动物未出现严重中毒表现,各脏器无病理性变化。结论长期大剂量服用塞隆骨替代豹骨后再造丸未见明显毒性。
Objective To study the acute toxicity and long-term toxicity of Sarong bone replacement leopard bone. Methods The maximal tolerance (MTD) method was used to test the acute toxicities of Salivary bones replaces leopard bones and then made pellets. The long-term toxicity test in rats was given by gavage for 26 weeks, Each group was sacrificed 10 and 20 animals, the rest of the animals were discontinued for 4 weeks observation period, observe the diet, activity, weight, food intake, appearance and other signs, and blood, biochemistry, pathology and other tests. Results No animal death was observed in the acute toxicity test. The MTD was 20 g / kg, which was equivalent to 156 times of the human clinical dose (0.128 g / kg). There was no severe poisoning in long-term toxicity animals and no pathological changes in various organs. Conclusion Long-term high-dose dressing Sarong instead of leopard bone and then shot no significant toxicity.