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近年来,许多学者就环孢素A(cyclosporine A,简称CsA)的肾毒性,进行了日趋深入的研究,但目前各家报道不一,许多问题还存在争议。实验动物的研究,由于其显而易见的特点和众所周知的原因,在这方面的工作具有重要的地位。本文仅就实验性CsA的肾毒性(CsA-NT)综述如下。一、实验动物的敏感性临床上按照应用CsA后肾功能损害出现的时间、程度及特点,将CsA-NT分为急性、亚急性和慢性三种类型,但各种类型无论是功能还是结构方面,均缺乏特异性的改变,因此,临床上常难以和排异反应或其它因素引起的肾功能损害相鉴别。动物对CsA-NT的敏感具有明显的种
In recent years, many scholars have conducted more and more researches on the nephrotoxicity of cyclosporine A (CsA). However, at present, various reports vary and many issues are still in dispute. The study of laboratory animals has an important place in this field because of its obvious characteristics and well-known causes. This article reviews the nephrotoxicity (CsA-NT) of experimental CsA only. First, the sensitivity of experimental animals Clinically according to the application of CsA renal dysfunction after the emergence of the time, degree and characteristics of CsA-NT divided into acute, subacute and chronic three types, but the various types of both functional and structural aspects , Are lack of specific changes, therefore, clinically difficult to differentiate and renal failure caused by other factors or differentiate. Animals have a clear species sensitivity to CsA-NT