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药物制剂,如酊剂、醑剂、酏剂、搽剂及大多数醇提取物中乙醇含量的测定,过去都将制剂经过蒸溜后按照测比重的方法进行,其操作费时。当制剂中有挥发性物质或有机溶剂存在时,制剂需经前处理后再蒸溜;即使如此,蒸溜液仍带有混浊,影响乙醇含量的测定,准确度也不高。这就需要一种快速、可靠和简便的方法来定量分析这些样品中的乙醇。实验证明,用气相色谱法对制剂中乙醇含量的测定能达到快速简便的效果,结果亦较准确。我组于1974年开始在国产100型气相层析仪上,摸索含醇量的测定。以后,根据高分子多孔微球的优点,采用了国产401有机担体,它能分离甲醇、乙醇及正丙醇混合液(见图1),于是以正丙醇作内标,用气固法测定了15种
The determination of ethanol content in pharmaceutical preparations such as tinctures, elixirs, elixirs, liniments, and most alcohol extracts has traditionally been carried out according to the specific gravity method after being distilled, which takes time and labor. When the preparation of volatile substances or organic solvents exist, the preparation need to be pre-treated and then steamed; even so, still with a cloudy solution, the determination of ethanol content, accuracy is not high. This requires a fast, reliable and easy way to quantify the ethanol in these samples. Experiments show that the use of gas chromatography on the determination of ethanol content in the preparation can achieve quick and easy results, the results are more accurate. My group began in 1974 in the domestic 100-type gas chromatograph, to explore the determination of alcohol content. Later, according to the advantages of polymer porous microspheres, using a domestic 401 organic carrier, which can separate methanol, ethanol and n-propanol mixture (see Figure 1), so n-propanol as an internal standard, measured by gas-solid method 15 kinds